Digitalization is changing our society and the working world, creating new processes and radically altering existing workflows. Aerospace is being impacted like every other scientific field, and innovation without digitalization is no longer conceivable. The three-part MOOC series “Digitalisation in Aeronautics and Space” is thus devoted to examining the transformations that have already occurred and forthcoming likely changes, posing the question: what will aerospace science be like in the future, and what will the influence of digitalization be on research? An array of research fields are focused on this question, including artificial intelligence in earth observation, robots in production, and digital avionics networks.